Silent Scream (1980) was filmed in at The Smith Estate in Los Angeles. and it was previously known as the Merrye house in the cult classic Spider Baby or, The Maddest Story Ever Told (1964). In both instances the house was chosen because it stands upon a hill, which made it easier to shoot wide angles and obscure the view of the neighboring homes in order to achieve a sense that the house is very isolated.
Barbara Steele took the role of Victoria in Silent Scream (1980) because it afforded her a rare opportunity to play a mute character. Her scenes were shot in four days.
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Silent Scream (1980) was originally shot in the summer of 1977. However, the original version was considered unreleasable. Director Denny Harris turned to screenwriters Jim Wheat and Ken Wheat to help improve the story, but they had the radical idea to reshoot the bulk of the film. The actors and actresses who played the college students were brought back for reshoots in March 1978. Yvonne De Carlo, Barbara Steele, Cameron Mitchell, and Avery Schreiber were all brought in during reshoots for name-recognition value, replacing the actors who originally played their roles. In the end, only 12 minutes of footage from the original version was retained in the final finished film.